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Vitamins side effect5/1/2023 ![]() For Cialis for use as needed, over 13 subjects were treated for at least 6 months and 1 year, respectively. In trials of Cialis for once daily use, a total of 1434, 905, and 115 were treated for at least 6 months, 1 year, and 2 years, respectively. Tadalafil was administered to over 9000 men during clinical trials worldwide. PDE5 inhibitors such as Cialis may affect platelet function and therefore prolong bleeding.Ĭialis should be used cautiously in patients with bleeding disorders or active ulcers.Ĭialis should not be combined with Adcirca (another form of tadalafil) or other PDE5 inhibitors.Ĭialis is not approved for women and is not intended for use in women who are pregnant or breastfeeding.Ĭialis (tadalafil) side effects list for healthcare professionals Clinical Trials Experienceīecause clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In patients taking nitrates for angina, Cialis could cause heart pain or possibly even a heart attack by exaggerating the increase in heart rate and the lowering of blood pressure.Ĭialis also exaggerates the blood pressure lowering effects of some alpha-blocking drugs that primarily are used for treating high blood pressure or enlargement of the prostate (BPH).Ĭombining Cialis with alcohol may cause excessive drops in blood pressure and cause dizziness, headaches, and increased heart rate. The following drugs may decrease blood levels of Cialis, possibly reducing the effect of Cialis: an erection that is painful or lasts longer than 4 hours ( priapism).ĭrug interactions of Cialis include the following drugs, which may increase levels of Cialis in the blood:.The mechanism whereby Cialis improves the symptoms of BPH is not clear, but phosphodiesterase-5 also is present in the muscles of the bladder and the prostate, and it has been suggested that the relaxation of these muscles may make the passage of urine less difficult by reducing the pressure in the muscle surrounding the opening to the urethra that controls the flow of urine from the bladder. ![]() The persistence of cGMP leads to a more prolonged erection. Cialis prevents phosphodiesterase-5 from destroying cGMP so cGMP stays around longer. When cGMP is destroyed the enzyme phosphodiesterase-5, the blood vessels return to normal size, blood leaves the penis, and the erection ends. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis that causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP) that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis and causing an erection. Does Cialis (tadalafil) cause side effects?Ĭialis ( tadalafil) is a phosphodiesterase-5 (PDE5) inhibitor used to treat impotence (the inability to attain or maintain a penile erection) and benign prostatic hyperplasia ( BPH).Įrection of the penis is caused by the filling of the penis with blood which occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.
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